Mapyrogens, anonziwo endotoxins, anogadzirwa mu extracellular wall yeGram-negative bacteria, kureva, zvidimbu zvezvitunha zvebhakitiriya.Icho chinhu che lipopolysaccharide ine hukama hwema molecular mass kubva pazviuru zvakati kusvika kumazana ezviuru, zvichienderana nemhando yebhakitiriya inoubudisa.Mumushonga wemvura, huremu hwayo hunogona kusiyana kubva kumazana ezviuru kusvika kumamiriyoni
Kana chidimbu che pyrogen chikasanganiswa mumushonga uye chikaiswa muropa remunhu, zvinokonzeresa kupisa kwakanyanya uye kunyange rufu.Naizvozvo, zvinonyanya kukosha kudzikisa iyo pyrogen yemukati mumushonga wemushonga zvakanyanya sezvinobvira, kunyanya kana jekiseni (seyakakura infusion) dosage yakakura, iyo yekumisikidza inodiwa yepyrogen inofanira kunge yakanyanya kuomarara.
Depyrogenation yemvura yejekiseni (kana mvura yejekiseni) chinhu chakakosha chekugadzira chinongedzo muindasitiri yemishonga kuti iite kuti isangane nemirairo yekuyedza yePharmacopoeia.Parizvino, nzira dze depyrogenation dzinowanzo kuunzwa muzvikamu zvitatu zvinotevera:
1. Distillation nzira inobereka depyrogenated mvura, iyo inoshandiswa semvura yejekiseni, yekugeza mvura, nezvimwewo, asi mari yayo yakakwirira.
2. Depyrogenation ne adsorption nzira.Imwe yenzira ndeyekuti iyo yepamusoro adsorbent inoshambadza iyo pyrogenic zvinhu uye inobvumira chigadzirwa zvinhu kupfuura.Nzira yechipiri ndeyokuti adsorbent adsorbs chigadzirwa uye inobvumira pyrogen kubuda kunze.
3. Membrane separation method yekubvisa pyrogen senzira itsva uye tekinoroji itsva iri kufarirwa uye inoshandiswa muindasitiri yemishonga.Nheyo ye ultrafiltration kubvisa pyrogen ndeye kushandisa ultrafiltration membrane idiki pane molecular huremu hwepyrogen kubata pyrogen.Iyi nzira yakasimbiswa.Uye ine mabhenefiti ekushomeka kwevashandi, goho remhando yepamusoro uye kunaka kwechigadzirwa.
Nguva yekutumira: Kubvumbi-20-2022